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Internship
Empress: Proteomics Co-Op
Flagship Pioneering · Co-Ops & Internships
- Where
- Somerville, MA USA
- Posted
- Sep 4
We're looking for a Co-Op to join our Proteomics team and contribute to the development of Empress's Integromyx and Perturb-seq platforms. You'll get hands-on experience across the full mass spectrometry-based proteomics workflows, from cell culture and sample preparation through LC-MS/MS acquisition on Orbitrap systems, including exposure to chemoproteomics experiments that sit at the intersection of chemistry and biology.
You'll work as part of a cross-functional team where your contributions matter from day one. We're looking for someone who is curious, detail-oriented, and eager to develop their skills alongside a team building something new.
What you'd do
- Set up, maintain, and operate Orbitrap mass spectrometry and associated liquid chromatography systems
- Maintain mammalian cell cultures; prepare growth media and expand cells for experiment setup
- Execute proteomics sample preparation workflows including protein extraction, fractionation, and LC-MS analysis
- Use laboratory automation for sample preparation and processing
- Contribute to proteomics and chemoproteomics experiments and support data analysis
- Present findings in team and cross-functional meetings; maintain meticulous electronic lab notebook records
What they want
- Currently enrolled in a B.S. or M.S. program in Chemistry, Chemical Biology, Biochemistry, or a related field
- Coursework or hands-on laboratory experience in chemical biology, liquid chromatography, or mass spectrometry
What you get
- Build alongside founders. You’ll work inside the same hypothesis-driven process Flagship uses to conceive and launch first-in-category companies.
- This can be the start of a longer story. Strong co-ops are considered for future opportunities across Flagship and its portfolio companies, not just for this one role.
- Work alongside people who left the safe path. Your colleagues are scientists, engineers, and operators who chose to build something new rather than join something already established.
- Take on real ownership. You're contributing to ventures that are still being defined. Your work can shape real decisions, not just support them.
- Be paid like the contributor you are. Compensation reflects the real work you take on.
About Flagship Pioneering · Co-Ops & Internships
Empress is pioneering mechanistic intelligence for drug discovery — helping R&D teams understand what their molecules are doing, what is driving activity, what liabilities may emerge, and which candidates are best positioned to advance. By integrating multi-omics, chemoproteomics, proteomics, transcriptomics, computational inference, knowledge graphs, and CRISPR-based functional validation, Empress turns biological complexity into clearer development decisions.